Speech dysfunction in early Parkinson's disease
Identifieur interne : 005827 ( Main/Exploration ); précédent : 005826; suivant : 005828Speech dysfunction in early Parkinson's disease
Auteurs : Stewart [États-Unis] ; Linda Winfield [États-Unis] ; Ann Hunt [États-Unis] ; Susan B. Bressman [États-Unis] ; Stanley Fahn [États-Unis] ; Andrew Blitzer [États-Unis] ; Mitchell F. Brin [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1995-09.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (therapeutic use), Articulation Disorders (complications), Deprenyl, Dysarthria (complications), Dysarthria (diagnosis), Humans, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson's disease, Selegiline (administration & dosage), Selegiline (therapeutic use), Severity of Illness Index, Speech dysfunction, Voice Disorders (complications).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Selegiline.
- chemical , therapeutic use : Antiparkinson Agents, Selegiline.
- complications : Articulation Disorders, Dysarthria, Parkinson Disease, Voice Disorders.
- diagnosis : Dysarthria.
- drug therapy : Parkinson Disease.
- Adult, Aged, Humans, Middle Aged, Severity of Illness Index.
Abstract
The purpose of this study is to determine if subjects in the early stages of untreated Parkinson's disease (PD) or PD treated with deprenyl alone suffer from motor speech abnormalities. Speech defects are common in advanced PD, including distrubances of respiration, phonation, and articulation. We studied 12 subjects with early PD (Hoehn and Yahr stage ≤2, mean duration disease 3.2 years) who were not taking symptomatic therapy and tested them under two conditions: on and off deprenyl. None of the subjects was depressed or demented (Mini Mental Status mean 29.9/30; Hamilton Depression Rating mean 2.7/52). All functioned independently (Schwab and England Activities of Daily Living mean 93.1/100). Acoustic and speech productions were assessed using the DSP Sona‐Graph 5500 and an evaluation of dysarthria. All 12 had at least two characteristics of dysarthria on examination, although 8 were not aware of it. Vocal tremor was identified on narrow band spectrogram for four subjects. Deprenyl did not have a consistent effect on speech. Ten subjects had no detectable change in speech on deprenyl, one was worse, and one was improved.
Url:
DOI: 10.1002/mds.870100506
Affiliations:
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Bressman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea></affiliation></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea></affiliation></author><author><name sortKey="Blitzer, Andrew" sort="Blitzer, Andrew" uniqKey="Blitzer A" first="Andrew" last="Blitzer">Andrew Blitzer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Otolaryngology, Roosevelt Hospital, New York</wicri:cityArea></affiliation></author><author><name sortKey="Brin, Mitchell F" sort="Brin, Mitchell F" uniqKey="Brin M" first="Mitchell F." last="Brin">Mitchell F. Brin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Mount Sinai School of Medicine and Mount Sinai Hospital, New York</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-09">1995-09</date><biblScope unit="vol">10</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="562">562</biblScope><biblScope unit="page" to="565">565</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5E6431361D4FCB8C12DF7F6FAD4E178E0C9F801E</idno><idno type="DOI">10.1002/mds.870100506</idno><idno type="ArticleID">MDS870100506</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Articulation Disorders (complications)</term><term>Deprenyl</term><term>Dysarthria (complications)</term><term>Dysarthria (diagnosis)</term><term>Humans</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson's disease</term><term>Selegiline (administration & dosage)</term><term>Selegiline (therapeutic use)</term><term>Severity of Illness Index</term><term>Speech dysfunction</term><term>Voice Disorders (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Selegiline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Selegiline</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Articulation Disorders</term><term>Dysarthria</term><term>Parkinson Disease</term><term>Voice Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dysarthria</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study is to determine if subjects in the early stages of untreated Parkinson's disease (PD) or PD treated with deprenyl alone suffer from motor speech abnormalities. Speech defects are common in advanced PD, including distrubances of respiration, phonation, and articulation. We studied 12 subjects with early PD (Hoehn and Yahr stage ≤2, mean duration disease 3.2 years) who were not taking symptomatic therapy and tested them under two conditions: on and off deprenyl. None of the subjects was depressed or demented (Mini Mental Status mean 29.9/30; Hamilton Depression Rating mean 2.7/52). All functioned independently (Schwab and England Activities of Daily Living mean 93.1/100). Acoustic and speech productions were assessed using the DSP Sona‐Graph 5500 and an evaluation of dysarthria. All 12 had at least two characteristics of dysarthria on examination, although 8 were not aware of it. Vocal tremor was identified on narrow band spectrogram for four subjects. Deprenyl did not have a consistent effect on speech. Ten subjects had no detectable change in speech on deprenyl, one was worse, and one was improved.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Stewart" sort="Stewart" uniqKey="Stewart" last="Stewart">Stewart</name></region><name sortKey="Blitzer, Andrew" sort="Blitzer, Andrew" uniqKey="Blitzer A" first="Andrew" last="Blitzer">Andrew Blitzer</name><name sortKey="Bressman, Susan B" sort="Bressman, Susan B" uniqKey="Bressman S" first="Susan B." last="Bressman">Susan B. Bressman</name><name sortKey="Brin, Mitchell F" sort="Brin, Mitchell F" uniqKey="Brin M" first="Mitchell F." last="Brin">Mitchell F. Brin</name><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><name sortKey="Hunt, Ann" sort="Hunt, Ann" uniqKey="Hunt A" first="Ann" last="Hunt">Ann Hunt</name><name sortKey="Stewart" sort="Stewart" uniqKey="Stewart" last="Stewart">Stewart</name><name sortKey="Winfield, Linda" sort="Winfield, Linda" uniqKey="Winfield L" first="Linda" last="Winfield">Linda Winfield</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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